Publications citing SporoCore products

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2024

Mansfield CR, Quan B, Chirgwin ME, et al. Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome. Cell Chem Biol. Published online March 13, 2024. https://doi.org/10.1016/j.chembiol.2024.02.008

McLellan J L, Garcia-Vilanova A, Hanson, KK. An Optimized P. berghei Liver Stage-HepG2 Infection Model for Simultaneous Quantitative Bioimaging of Host and Parasite Nascent Proteomes. Bio-protocol, (2024) 14(5), e4952. https://doi.org/10.21769/BioProtoc.4952

Mitchell G, Torres, L, Fishbaugher, ME et al. “Correlative light-electron microscopy methods to characterize the ultrastructural features of the replicative and dormant liver stages of Plasmodium parasites.” Malar J (2024):23, 53. https://doi.org/10.1186/s12936-024-04862-w

Schroeder EA, Toro-Moreno M, Raphemot R, Sylvester K, Colón IC, Derbyshire ER. “Toxoplasma and Plasmodium associate with host Arfs during infection.” mSphere (2024):e00770-23. https://doi.org/10.1128/msphere.00770-23

Wang, Lushun, Monica J. Bohmer, Jinhua Wang, Flore Nardella, Jaeson Calla, Mariana Laureano De Souza, Kyra A. Schindler et al. “Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.”Journal of Medicinal Chemistry (2024): Article ASAP. https://doi.org/10.1021/acs.jmedchem.3c02046

2023

Marques-da-Silva, Camila, Clyde Schmidt-Silva, Rodrigo P. Baptista, Samarchith P. Kurup; “Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection.” J Immunol (2023); ji2300440. https://doi.org/10.4049/jimmunol.2300440

McLellan, James L., William Sausman, Ashley B. Reers, Evelien M. Bunnik, and Kirsten K. Hanson. “Single-cell quantitative bioimaging of P. berghei liver stage translation.” mSphere 8, no. 6 (2023): e00544-23. https://doi.org/10.1128/msphere.00544-23

Reers, Ashley B., Rodriel Bautista, James McLellan, Beatriz Morales, Rolando Garza, Sebastiaan Bol, Kirsten K. Hanson, and Evelien M. Bunnik. “Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites.” Epigenetics & Chromatin 16, no. 1 (2023): 1-25. https://doi.org/10.1186/s13072-023-00500-y

Maher, Steven P., Malina A. Bakowski, Amelie Vantaux, Erika L. Flannery, Chiara Andolina, Mohit Gupta, Yevgeniya Antonova-Koch et al. “A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites.” bioRxiv (2023): 2023-01. https://doi.org/10.1101/2023.01.31.526483

Ong, Han Wee, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael Chirgwin et al. “Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.” European Journal of Medicinal Chemistry 249 (2023): 115043. https://doi.org/10.1016/j.ejmech.2022.115043

Istvan, Eva S., Francisco Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu et al. Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15, no. 686 (2023): eadc9249. https://doi.org/10.1126/scitranslmed.adc9249

Marques-da-Silva, Camila, Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau, Lecia L. Pewe et al. AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes. Proceedings of the National Academy of Sciences 120, no. 2 (2023): e2210181120. https://doi.org/10.1073/pnas.2210181120

2022

Bowers, C., L. Hancox, K. Peissig, J. C. Shiau, A. Vantaux, B. Witkowski, S. Phal, S. P. Maher, J. T. Harty, and D. E. Kyle. Cryopreservation of Plasmodium Sporozoites. Pathogens 2022, 11, 1487.” (2022). https://doi.org/10.3390/pathogens11121487

Marques-da-Silva, Camila, Kristen Peissig, Michael P. Walker, Justine Shiau, Carson Bowers, Dennis E. Kyle, Rahul Vijay, Scott E. Lindner, and Samarchith P. Kurup. Direct type I interferon signaling in hepatocytes controls malaria. Cell reports 40, no. 3 (2022): 111098. https://doi.org/10.1016/j.celrep.2022.111098

Mughal, Haseeb, Elise C. Bell, Khadija Mughal, Emily R. Derbyshire, and Joel S. Freundlich. Random Forest Model Predictions Afford Dual-Stage Antimalarial Agents. ACS infectious diseases 8, no. 8 (2022): 1553-1562. https://doi.org/10.1021/acsinfecdis.2c00189

Botnar, Alona, Grant Lawrence, Steven P. Maher, Amélie Vantaux, Benoît Witkowski, Justine C. Shiau, Emilio F. Merino et al. Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp. International Journal for Parasitology 52, no. 11 (2022): 733-744. https://doi.org/10.1016/j.ijpara.2022.03.003

Calla, Jaeson, Nimisha Mittal, Greg LaMonte, Benjamin Liffner, Karla P. Godinez-Macias, Krypton Carolino, Gregory T. Walker et al. Plasmodium exoerythrocytic parasites redirect trafficking of human proteins to the parasitophorous vacuole. bioRxiv (2022): 2022-11. https://doi.org/10.1101/2022.11.22.517223

Tye, Mark A., N. Connor Payne, Catrine Johansson, Kritika Singh, Sofia A. Santos, Lọla Fagbami, Akansha Pant et al. “Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.” Nature Communications 13, no. 1 (2022): 4976. https://doi.org/10.1038/s41467-022-32630-4

Galal, Kareem A., Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael E. Chirgwin et al. “Identification of Novel 2, 4, 5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/Pf PK6 with Activity against Blood Stage Parasites In Vitro.” Journal of Medicinal Chemistry 65, no. 19 (2022): 13172-13197. https://doi.org/10.1021/acs.jmedchem.2c00996

2021

Lefebvre, Mitchell N., Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox et al. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell reports 37, no. 5 (2021): 109956. https://doi.org/10.1016/j.celrep.2021.109956

Lefebvre, Mitchell N., Lisa L. Drewry, Lecia L. Pewe, Lisa S. Hancox, Arturo Reyes-Sandoval, and John T. Harty. Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites. The Journal of Immunology 207, no. 11 (2021): 2631-2635. https://doi.org/10.4049/jimmunol.2100818

Marques-da-Silva, Camila, Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau, Lecia L. Pewe et al. Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver. Biorxiv (2021): 2021-01. https://doi.org/10.1101/2021.01.28.427517

Sylvester, Kayla, Steven P. Maher, Dora Posfai, Michael K. Tran, McKenna C. Crawford, Amélie Vantaux, Benoit Witkowski, Dennis E. Kyle, and Emily R. Derbyshire. Characterization of the tubovesicular network in Plasmodium vivax liver stage hypnozoites and schizonts. Frontiers in Cellular and Infection Microbiology 11 (2021): 687019. https://doi.org/10.3389/fcimb.2021.687019